Contact infos

  • email: blandine.comte{at}inrae{dot}fr
  • phone: +33(0)4 73 62 46 87

I am leading the MAPPING (MetAbolic PhenotyPe, nutrItioN and modelinG) research group within the Plateforme d’Exploration du Métabolisme, focused on studying the characteristics of the first metabolic deviations associated with the development of non-communicable diseases (metabolic syndrome, type 2 diabetes, pre-frailty/frailty), using systems biology integrative approaches: modeling, simulation, combining multi-scale experimental data (omics and other). 


Research interests

  • Knowledge on the mechanisms by which nutrition, macro- and micronutrients contribute to the development or prevention of chronic metabolic diseases using metabolomic approaches, thanks to multidimensional approaches to build models and reveal the determinants and modulators of these changes: identification of early metabolic deviations, and identification of status and/or predictive biomarkers for better metabolic phenotyping.
  • Development of new tools of the high throughput approaches for research on metabolism and nutrition to identify biomarkers of exposure and effects and a better stratification of at-risk populations.


Main publications

  • Comte B, Monnerie S, Brandolini-Bunlon M, Canlet C, Castelli F, Chu-Van E, Colsch B, Fenaille F, Joly C, Jourdan F, Lenuzza N, Lyan B, Martin J-F, Migné C, Morais J-A, Pétéra M, Poupin N, Vinson F, Thevenot E, Junot C, Gaudreau P, Pujos-Guillot E. Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men. EBioMed. 2021, 69, 103440.
    doi: 10.1016/j.ebiom.2021.103440
  • Comte B, Baumbach J, Benis A, Basílio J, Debeljak N, Flobak Å, Franken C, Harel N, He F, Kuiper M, Méndez Pérez J-A, Pujos-Guillot E, Režen T, Rozman D, Schmid J.A., Scerri J, Tieri P, Van Steen K, Vasudevan S, Watterson S, and Schmidt H.H.H.W.. Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine. Network and Systems Med. 2020 Jul.
    doi: 10.1089/nsm.2020.0004,
  • Monnerie S, Comte B, Ziegler D, Morais JA, Pujos-Guillot E, Gaudreau P. Metabolomic and lipidomic signatures of metabolic syndrome and its physiological components in adults: A systematic review. Sci Rep. 2020 Jan 20;10(1):669.
    doi: 10.1038/s41598-019-56909-7.
  • Pujos-Guillot E, Pétéra M, Jacquemin J, Centeno D, Lyan B, Montoliu I, Madej D, Pietruszka B, Fabbri C, Santoro A, Brzozowska A, Franceschi C, Comte B. Identification of pre-frailty sub-phenotypes in elderly using metabolomics. Frontiers Physiol. 2019, Jan 24;9:1903.
    doi: 10.3389/fphys.2018.01903.
  • Pujos-Guillot E, Brandolini-Bunlon M, Pétéra M, Grissa D, Joly C, Lyan B, Herquelot E, Czernichow S, Zins M, Goldberg M, Comte B. Systems Metabolomics for Prediction of Metabolic Syndrome. J. Prot Res. 2017. 16 (6), 2262-2272.
    doi: 10.1021/acs.jproteome.7b00116.
  • Polakof S, Dardevet D, Mosoni L, Gatineau E, Martin J-F, Pujos-Guillot E, Mazur A, Comte B. The time course of molecular and metabolic events in the development of insulin resistance in fructose-fed rats. J Prot. Res. 2016 Jun 3;15(6):1862-74.
    doi: 10.1021/acs.jproteome.6b00043.
  • Morio B, Comte B, Martin JF, Chanseaume E, Alligier M, Junot C, Boirie Y, Vidal H, Laville M, Pujos-Guillot E, Sebedio JL. Metabolomics reveals differences in subtle metabolic changes following lipid overnutrition of normal and overweight subjects. Metabolomics 2015, 11(4):920-38. 2015.
    doi: 10.1007/s11306-014-0750-y
  • Martinez E, Deval C, Jousse C, Mazur A, Brachet P, Comte B. Methyl donor deficiency in H9C2 cardiomyoblasts induces ER stress as an important part of the proteome response. Intern J Biochem & Cell Biol. 2015, 59:62-72. Epub 2014 Dec 6, 2015.
    doi: 10.1016/j.biocel.2014.11.013