Contact infos

  • estelle.pujos-guillot{at}inrae{dot}fr
  • phone: +33(0)4 73 62 41 41

I am the scientific manager of the PFEM and my mission is to manage the team and the platform on one hand; and on the other hand, to carry out methodological developments in metabolomics as well as the to build pilot research projects to position metabolomics in systems biology.


Development of mass spectrometry-based analytical methods and bioinformatics tools for a better characterization of the first metabolic deviations associated with development of chronic metabolic diseases and to determine the relative contribution of the different determinants linked to these changes (part of the food): 

  • metabolic profiling using multiplatform approaches (UPLC/QToF, GC/ToF) to gain a broad coverage of the metabolites present in biofluids and tissues.
  • development of analytical strategies for biomarker identification using ultra high-resolution mass spectrometry and bioinformatics tools.
  • development of models and tools to increase knowledge extraction from high throughput data.


Main publications

  • Comte B, Monnerie S, Brandolini-Bunlon M, Canlet C, Castelli F, Chu-Van E, Colsch B, Fenaille F, Joly C, Jourdan F, Lenuzza N, Lyan B, Martin J-F, Migné C, Morais J-A, Pétéra M, Poupin N, Vinson F, Thevenot E, Junot C, Gaudreau P, Pujos-Guillot E. Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men. EBioMed. 2021, 69, 103440.
    doi: 10.1016/j.ebiom.2021.103440
  • Brandolini-Bunlon M, Petera M, Gaudreau P, Comte B, Bougeard S, Pujos-Guillot E. Multi-block PLS discriminant analysis for the joint analysis of metabolomic and epidemiological data. Metabolomics 2019; 15(10).
    doi: 10.1007/s11306-019-1598-y.
  • Pujos-Guillot E, Petera M, Jacquemin J, Centeno D, Lyan B, Montoliu I, Madej D, Pietruszka B, Fabbri C, Santoro A, Brzozowska A, Franceschi C, Comte B. Identification of Pre-frailty Sub-Phenotypes in Elderly Using Metabolomics. Front in Physiol 2019; 9.
    doi: 10.3389/fphys.2018.01903
  • Pujos-Guillot E, Brandolini M, Petera M, Grissa D, Joly C, Lyan B, Herquelot E, Czernichow S, Zins M, Goldberg M, Comte B. Systems Metabolomics for Prediction of Metabolic Syndrome. J Prot Res 2017; 16(6): 2262-72.
    doi: 10.1021/acs.jproteome.7b00116
  • Grissa D, Petera M, Brandolini M, Napoli A, Comte B, Pujos-Guillot E. Feature Selection Methods for Early Predictive Biomarker Discovery Using Untargeted Metabolomic Data. Front Mol Biosci 2016; 3: 30.
    doi: 10.3389/fmolb.2016.00030
  • Pujos-Guillot E, Hubert J, Martin JF, Lyan B, Quintana M, Claude S, Chabanas B, Rothwell JA, Bennetau-Pelissero C, Scalbert A, Comte B, Hercberg S, Morand C, Galan P, Manach C. Mass Spectrometry-based Metabolomics for the Discovery of Biomarkers of Fruit and Vegetable Intake: Citrus Fruit as a Case Study. Journal of Proteome Research 2013; 12(4): 1645-59.
    doi: 10.1021/pr300997c
  • Gao XF, Pujos-Guillot E, Sebedio JL. Development of a Quantitative Metabolomic Approach to Study Clinical Human Fecal Water Metabolome Based on Trimethylsilylation Derivatization and GC/MS Analysis. Anal Chem 2010; 82(15): 6447-56.
    doi: 10.1021/​ac1006552.
  • Pereira H, Martin JF, Joly C, Sebedio JL, Pujos-Guillot E. Development and validation of a UPLC/MS method for a nutritional metabolomic study of human plasma. Metabolomics 2010; 6(2): 207-18.